Normal circulating serum amyloid P component concentration in systemic sclerosis
نویسندگان
چکیده
منابع مشابه
Serum amyloid A protein concentration in progressive systemic sclerosis (scleroderma).
Serum amyloid A protein (SAA) concentrations were determined in 62 patients with progressive systemic sclerosis (PSS). Forty-seven patients had normal or slightly elevated SAA levels (less than 1000 ng/ml = micrograms/l), while 15 patients had moderately to markedly elevated SAA levels, similar to those observed in active rheumatoid arthritis (RA) (greater than or equal to 1000 ng/ml = microgra...
متن کاملSerum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis.
Extracellular deposition of amyloid fibrils is responsible for the pathology in the systemic amyloidoses and probably also in Alzheimer disease [Haass, C. & Selkoe, D. J. (1993) Cell 75, 1039-1042] and type II diabetes mellitus [Lorenzo, A., Razzaboni, B., Weir, G. C. & Yankner, B. A. (1994) Nature (London) 368, 756-760]. The fibrils themselves are relatively resistant to proteolysis in vitro b...
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Amyloid P component (AP) 1 is a glycoprotein found in all forms of amyloid deposit regardless of the chemical nature of the fibril protein (1-6). It is indistinguishable from a normal plasma protein, serum amyloid P component (SAP), in terms of antigenicity, molecular weight, polypeptide subunit composition, appearance in the electron microscope, and the partial amino acid sequences available h...
متن کاملThe liver in systemic amyloidosis: insights from 123I serum amyloid P component scintigraphy in 484 patients.
BACKGROUND AND AIMS The liver is frequently involved in amyloidosis but the significance of hepatic amyloid has not been systematically studied. We have previously developed scintigraphy with 123I serum amyloid P component (123I-SAP) to identify and monitor amyloid deposits quantitatively in vivo and we report here our findings in hepatic amyloidosis. METHODS Between 1988 and 1995, 805 patien...
متن کاملAnti-serum amyloid component P antibodies in patients with systemic lupus erythematosus correlate with disease activity.
OBJECTIVE To determine the presence of raised titres of anti-serum amyloid P component (SAP) antibodies in patients with systemic lupus erythematosus (SLE) and to evaluate their correlation with clinical disease by the SLEDAI and clinical manifestations. METHODS 452 samples were screened for raised anti-SAP antibody titres by an ELISA. Clinical measures and SLEDAI scores were independently re...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2007
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.22694